Our Liquid Biopsy Technology

Lucence develops blood tests that detect cancer more quickly, accurately and cost-effectively. The tests are based on our proprietary amplicon-based liquid biopsy technology, which detects cancer signals in blood more accurately through amplification.

The simpler way to fight cancer

  • When tumor cells die, they release DNA fragments into the blood stream called circulating tumor DNA (ctDNA). ctDNA is widely used as a biomarker in cancer diagnosis and prognosis.
  • Our technology analyzes these DNA fragments to identify the mutations in each patient’s tumor. Based on clinical studies, certain genetic mutations have been shown to respond better to specific targeted therapies.
  • This allows doctors to select the most appropriate cancer treatment according to the genetic mutations identified.

Early detection of cancer

Our liquid biopsy technology can be used for early cancer detection before symptoms show. Most cancers are currently detected in the late stages resulting in poor treatment outcome. Early detection will greatly improve survival rate and chances of cure.

Benefits of Liquid Biopsy


Non-invasive. Requires only a single draw of blood


Results back in days for timely treatment


Detects clinically actionable genetic mutations to improve cancer diagnosis and treatment selection

Our Core Innovative Technology

Lucence’s proprietary AmpliMARK™ technology powers our flagship liquid biopsy test – LiquidHALLMARK®, the world’s first blood test that detects both cancer-causing genes and viruses in order to match patients to the best treatment.

AmpliMARK™ is an amplicon-based sequencing technology with sensitivity and specificity of up to 99.9%. We invented this technology to detect cancer signals in blood with higher accuracy by signal amplification. Our technology detects genomic alterations in the cancer, including somatic mutations, microsatellite instability (MSI) and viral DNA, from circulating tumor DNA (ctDNA) in blood.

The improved accuracy and sensitivity of cancer detection by amplification will be a key foundation of early detection. We are now developing a test for detecting multiple cancers at the early stage towards our vision of a world with zero avoidable cancer deaths.

See our full range of diagnostic services. Learn More

Our Assurance

Clinically Validated

Our tests are clinically validated for accuracy and kept up to date with the latest clinical findings to provide the best possible diagnostic tests.

Accredited Laboratory

Our molecular diagnostics laboratory in Singapore is CAP and CLIA accredited. We are licensed by the Ministry of Health (Singapore) as a Clinical Laboratory (Licence No. 17I0039/2/182) under the Private Hospital and Medical Clinics Act.

Quality Standards

Our laboratory results are benchmarked with leading quality control agencies to match international standards and provide quality assurance to our customers.


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