Dr. Raj Patel 是一位擁有三十多年臨床經驗的委員會認證（Board-certified）醫師。他分享了克隆性造血（Clonal Hematopoiesis，CH）檢測的新興應用，以及血液中的基因資訊如何協助評估潛在的心血管疾病與白血病風險，支持更早期的介入與更個人化的預防照護。

心安康™ 是一項以液體活檢為基礎的次世代定序（NGS）檢測，運用 Lucence 專利的 Mirror Barcoding 技術，偵測與老化及生活型態相關的 CH 基因突變。請諮詢您的醫療機構，以獲取有關您的醫療方案的建議。

Lucence 的液體活檢產品並非作為伴隨診斷工具而設計或指定使用，亦非旨在取代醫師的臨床判斷，且並非用於診斷特定病症或疾病，亦非用於為特定病症或疾病確定適當的治療方案。

Patel 醫師所發表的言論僅代表其個人專業見解，未必代表 Lucence 作為組織的觀點。Patel 醫師是 Lucence 的受聘顧問。

影片字稿：

Younger people in the 40s and 50s are getting heart attacks, strokes. These are the people who don't meet traditional risk factors. So why is this happening? 

I'm Dr. Raj Patel. I am in practice for the last 34 years, and I'm a Board-certified physician. There are new tests coming on, and one of the tests that has really interested me is clonal hematopoiesis. What this test shows is there is a mutation in your stem cells. I read an article in the New England Journal of Medicine, and that study showed that if your stem cell shows a mutation, it will increase the risk of stroke, heart attack, and leukemia. 

So when we do this test, which is a simple blood test, what it shows is variant allele frequency, and this measures how many cells are abnormal. It gives us the signal that you may have inflammation in your blood vessels. Higher the mutated cells means higher inflammation, means higher risk of cardiovascular disease and leukemia.

I have done about 20 tests so far. Two cases are really mind-boggling to me.

One patient does have a family history of heart attack. He himself is obese and has hyperlipidemia. So when we did this test, his JAK2 mutation came back positive, which was shocking to me. I immediately referred him to the hematologist because I suspected that he is at risk or he may have leukemia.

Second patient, 50-year-old male, diabetes, hypertension, smoking for years. We did the test, came out positive, sat down, and I discussed, “You are at very high risk for heart attack and stroke.” I put him on daily aspirin. I called him after two weeks just to check on him. He hasn't had one cigarette since my visit, and he's taking his medication, including aspirin every day.

That's the power of this test, making a personalized test for everybody, which will change their lifestyle because it is their test. It is their result. This clonal hematopoiesis test does not replace what we are doing. This is a complementary test. We are catching this process at the earliest stage, and that's the beauty of this test. 

If you're 40 and above, if you just want to know that, “Am I at risk for stroke, heart attack, or leukemia?” Just talk to your doctor. It's a simple blood test, and in two weeks, you would have the answer.